Taryn Manning stars as inmate Tiffany Pennsatucky Doggett, a reformed meth addict and evangelical Christian.

Natasha Lyonne stars as inmate Nicky Nichols, a quick-witted recovering heroin addict.

Uzo Aduba stars as Suzanne 'Crazy Eyes' Warren, an unpredictable inmate with a crush on Piper.

Laverne Cox stars as Sophia Burset, a transgender inmate who serves as the prison’s resident beautician.

Laura Prepon stars as Alex Vause, Piper’s alluring international drug smuggler ex-girlfriend whose confession led to Piper's imprisonment.

Jason Biggs stars as Larry Bloom, Piper’s well-meaning fiancé who’s struggling to adjust to her new life behind bars.